when Pfizer and Moderna came out I already had decided not to have them because, amongst other reasons, they contain PEG. I have worked shortly in a cosmetics lab and know what PEGs are. The chemist told me 70% of people is allergic to it, that it is a very bad ingredient used in shampoo, and that, if you ask formulators why they still use it, where there are lots of safer products available, they answer: we have always done it like this.
When J&J came out, I saw it contains Polysorbate 80, which belongs in cosmetic chemistry to the same family of bad ingredients PEG/PPG. By then, I had already heard of several friends that the virus was not all that bad. Specially an older couple with lots of health problems told me it was like a mild flu. I decided if they survived it, so would I. I don't think I have been infected yet, or it would be one of these ghost infections ! Thanks for your articles. I am saving them. Need to re-read a few times.
IgG4 class switching would be a firm NO, regardless of anything else. It is a primate study, but if the S1 has the same epitopes it will be repeatable in humans.
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates (2023)
...However, the booster immunization predominantly induced an IgG4 response in all three groups. In addition, the NVX-CoV vaccines induced a 10-fold lower IgG1 response compared with the mRNA booster, with a statistically significant difference between the mRNA-1273 and NVX-CoV2515 groups. Consistent with a lower IgG1 response in the NVX-CoV groups, their antibodies had reduced binding to FcγRIIIA (Fig. 1F). Overall, these data demonstrate that the booster dose, regardless of vaccine, predominantly boosted the IgG4 response, and the NVX-CoV vaccines showed lower recall of IgG1 response (Fig. 1G). All three booster vaccines induced cross-reactive IgG1- and IgG4-binding antibody response against the spike and RBD proteins from other VOCs (Alpha, Beta, Delta, and Gamma and Omicron BA.1) with comparable response, except that the IgG1 response in the BA.1 vaccine was notably lower compared with the response induced by the mRNA-1273 vaccine (fig. S2).
when Pfizer and Moderna came out I already had decided not to have them because, amongst other reasons, they contain PEG. I have worked shortly in a cosmetics lab and know what PEGs are. The chemist told me 70% of people is allergic to it, that it is a very bad ingredient used in shampoo, and that, if you ask formulators why they still use it, where there are lots of safer products available, they answer: we have always done it like this.
When J&J came out, I saw it contains Polysorbate 80, which belongs in cosmetic chemistry to the same family of bad ingredients PEG/PPG. By then, I had already heard of several friends that the virus was not all that bad. Specially an older couple with lots of health problems told me it was like a mild flu. I decided if they survived it, so would I. I don't think I have been infected yet, or it would be one of these ghost infections ! Thanks for your articles. I am saving them. Need to re-read a few times.
Thanks very much Bine for all your contributions and sharing my posts. Wishing you and all your readers a Merry Christmas and Happy New Year.
Thank you Dr Bine.
IgG4 class switching would be a firm NO, regardless of anything else. It is a primate study, but if the S1 has the same epitopes it will be repeatable in humans.
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates (2023)
...However, the booster immunization predominantly induced an IgG4 response in all three groups. In addition, the NVX-CoV vaccines induced a 10-fold lower IgG1 response compared with the mRNA booster, with a statistically significant difference between the mRNA-1273 and NVX-CoV2515 groups. Consistent with a lower IgG1 response in the NVX-CoV groups, their antibodies had reduced binding to FcγRIIIA (Fig. 1F). Overall, these data demonstrate that the booster dose, regardless of vaccine, predominantly boosted the IgG4 response, and the NVX-CoV vaccines showed lower recall of IgG1 response (Fig. 1G). All three booster vaccines induced cross-reactive IgG1- and IgG4-binding antibody response against the spike and RBD proteins from other VOCs (Alpha, Beta, Delta, and Gamma and Omicron BA.1) with comparable response, except that the IgG1 response in the BA.1 vaccine was notably lower compared with the response induced by the mRNA-1273 vaccine (fig. S2).
https://www.science.org/doi/10.1126/sciimmunol.adg7015
Basically a spike-protein is a spike protein is a pike protein regardless the product. First rule of not to vaccine.