Activation of Antiviral Protein Kinase Leads to Immunoglobulin E Class Switching in Human B Cells
"... Here, we provide molecular evidence for the roles of viral infection and of activation of the antiviral protein kinase (PKR) (double-stranded-RNA [dsRNA]-activated protein kinase) in the induction of IgE class switching. The presence of dsRNA, a known component of viral infection and an activator of PKR, induced IgE class switching as detected by the expression of germ line ɛ in the human Ramos B-cell line. Furthermore, dsRNA treatment of Ramos cells resulted in the activation of PKR and in vivo activation of the NF-κB complex."
Liebe Dr. Sabine Stebel, wo kann man Sie anschreiben? Ich habe ähnliche Probleme wie Sie mit den Mastzellen und Komplementsystem, nichts hilft, was kann man noch versuchen? Antihistaminika vertrage ich nicht. Bin durch Shedding krank. Liebe Grüße, Eveline... Stehen in Ihrem Buch Lösungen?
Thank you.
The deliberate contaminant dsRNA, TH2 & IgE:
Activation of Antiviral Protein Kinase Leads to Immunoglobulin E Class Switching in Human B Cells
"... Here, we provide molecular evidence for the roles of viral infection and of activation of the antiviral protein kinase (PKR) (double-stranded-RNA [dsRNA]-activated protein kinase) in the induction of IgE class switching. The presence of dsRNA, a known component of viral infection and an activator of PKR, induced IgE class switching as detected by the expression of germ line ɛ in the human Ramos B-cell line. Furthermore, dsRNA treatment of Ramos cells resulted in the activation of PKR and in vivo activation of the NF-κB complex."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124593/
It's a mess. We need somebody from the systems biology department to model all this or an AI to extrapolate some models.
RAS is still missing in this mess. Sabatier did a lot of work on the Spike-RAS-Immunology connection.
Liebe Dr. Sabine Stebel, wo kann man Sie anschreiben? Ich habe ähnliche Probleme wie Sie mit den Mastzellen und Komplementsystem, nichts hilft, was kann man noch versuchen? Antihistaminika vertrage ich nicht. Bin durch Shedding krank. Liebe Grüße, Eveline... Stehen in Ihrem Buch Lösungen?