„Immunoregulatory effects of Huaier (Trametes robiniophila Murr) and relevant clinical applications“
„3.2.2 Effects of Huaier on macrophages“
…Skewed polarization of macrophages is implicated in neoplastic diseases as M1 macrophages often display antitumor effects while M2 macrophages usually facilitate tumor initiation and progression.
Based on the currently available publications that we collected (9, 23, 47), consistent results suggested that Huaier suppresses M2 polarization and promotes M1 polarization in various neoplastic diseases that probably mediated by the activation of the TLR4-NF-κB/MAPK signaling pathway.
Furthermore, the enhanced secretion of pro-inflammatory cytokines from Huaier-induced M1 macrophages might account for a great deal of Huaier-produced antitumor effects, as in vitro experiments only demonstrated weak direct tumor suppressive activity of the Huaier-derived proteoglycan TPG-1, whereas the IL-6 and TNF-α rich supernatant of TPG-1 treated macrophages showed a much stronger inhibiting effects on tumor growth (23)…..
As a start: e.g. nigella sativa, black cumin
https://doi.org/10.12688/f1000research.53713.1
etc.
Hab den Artikel mal unter seinem Tweet gepostet….😬😬😬
„Immunoregulatory effects of Huaier (Trametes robiniophila Murr) and relevant clinical applications“
„3.2.2 Effects of Huaier on macrophages“
…Skewed polarization of macrophages is implicated in neoplastic diseases as M1 macrophages often display antitumor effects while M2 macrophages usually facilitate tumor initiation and progression.
Based on the currently available publications that we collected (9, 23, 47), consistent results suggested that Huaier suppresses M2 polarization and promotes M1 polarization in various neoplastic diseases that probably mediated by the activation of the TLR4-NF-κB/MAPK signaling pathway.
Furthermore, the enhanced secretion of pro-inflammatory cytokines from Huaier-induced M1 macrophages might account for a great deal of Huaier-produced antitumor effects, as in vitro experiments only demonstrated weak direct tumor suppressive activity of the Huaier-derived proteoglycan TPG-1, whereas the IL-6 and TNF-α rich supernatant of TPG-1 treated macrophages showed a much stronger inhibiting effects on tumor growth (23)…..
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1147098/full
Die australische Pharmakologie und der Toxikologe Geoff Pain wähnen auf das Substanzziel, eine von Mφ sekretierte Substanz, als den Weg, den Endotoxin zu Krebs führt. https://geoffpain.substack.com/p/endotoxin-in-jabs-drives-tumour-associated?publication_id=1264116
https://hervk102.substack.com/p/the-marvels-of-the-herv-k102-virus?publication_id=661191
(Schaum Mφ)
Wie Sie betont haben, scheint es eine Vielzahl von Mφ in unterschiedlichem Medizinstudenten zu unterscheiden [Mφ∋M1φ, M2φ, Schaum Mφ, ⋯⋯].
👍
https://pmc.ncbi.nlm.nih.gov/articles/PMC9311967/
https://journal-inflammation.biomedcentral.com/articles/10.1186/s12950-023-00360-z
https://pmc.ncbi.nlm.nih.gov/articles/PMC5821995/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4244692/
Thanks. I added the information.