Für den Impfstoff M-M-RVaxPro gibt es keine präklinischen Sicherheitsstudien. Dieser Impfstoff wurde direkt am Menschen getestet.
IFG Anfrage an das PEI
Eigentlich nur ein Update zu diesem Artikel. Da aber kaum einer die Updates verfolgt oder mitbekommt, habe ich diesen Aspekt ausgegliedert, da ich glaube, dass diese IFG Anfrage wichtig für Eltern ist, die ihre Kinder nicht mit einem MMR Impstoff impfen lassen möchten.
IFG Anfrage: Präklinische Sicherheitsstudien der MMR-Impfstoffe - FragDenStaat
Bin ich froh unseren Kinderarzt cor kurzem erst regelrecht zu einer Titerbestimmung MMR gezwungen zu haben. Das ist ja irre was hier läuft.
Und siehe da, alle drei Titer waren hoch genug, dass hier kein Impfzwang im Sinne der zweiten MMR Impfung greifen konnte.
Leute, Leute....
Clastogenic Potential of Certain Vaccines on Bone Marrow Cells of Swiss Mice
R. C. ChoudhuryP. Sahu
Biology, Medicine
8 February 2003
The results were compared with the scantily available earlier data on the clastogenicity of vaccines and the live viruses in patients and the possible substance present in the vaccines causing chromosomal aberrations has been discussed.
Abstract
Abstract Although most of the vaccines are prepared out of the heat killed or attenuated virus and bacteria, study on their genotoxicity/clastogenicity is meagre. Therefore, the clastogenic potential of certain widely used vaccines namely, measles, rubella and rabies (rabipur), has been assessed at 24 h post-treatment from mouse bone marrow cells after a low dose, single intraperitoneal treatment. Mitotic metaphase spreads were scanned from the slides prepared following the colchicine-sodium citrate hypotonic-methanol, glacial acetic acid-flame drying-Giemsa technique. All the three treated doses of measles vaccine (500, 1000, 2000 CCID50 per 100 g b.w. of mice) induced significant chromosomal aberrations in male mice (P ≤ 0.05 or P ≤ 0.01), but failed to induce significant aberrations in female mice. Interestingly, the intermediate dose showed the optimum effects. All the three different doses of rubella vaccine (100, 200, or 400 CCID50 per 100 g b.w. of mice) induced statistically significant (P ≤ 0.01) chromosomal aberrations in both female and male mice. The induced chromosomal aberrations (P ≤ 0.01) by all the three different treated doses of rabies vaccine (0.25, 0.5, or 1.0 I.U. per 100 g b.w. of mice) were dose related but nonlinear. The results were compared with the scantily available earlier data on the clastogenicity of vaccines and the live viruses in patients. The possible substance present in the vaccines causing chromosomal aberrations has been discussed. — https://www.semanticscholar.org/search?q=%22Clastogenic%20Potential%20of%20Certain%20Vaccines%20on%20Bone%20Marrow%20Cells%20of%20Swiss%20Mice%22%2C&sort=relevance